Sodium Carbonate → HCID 71204729, compound

HRID 712860Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C@@H:2]1[C:7]([NH:9][C@H:10]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1)[CH3:11])=[O:8].[F:22][C:23]([F:33])([F:32])[C:24]1[CH:31]=[CH:30][C:27]([CH2:28]Br)=[CH:26][CH:25]=1.C([O-])([O-])=O.[Na+].[Na+]>>[F:22][C:23]([F:32])([F:33])[C:24]1[CH:31]=[CH:30][C:27]([CH2:28][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][C@@H:2]2[C:7]([NH:9][C@H:10]([C:12]2[CH:13]=[CH:14][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:20][CH:21]=2)[CH3:11])=[O:8])=[CH:26][CH:25]=1

Participants

Reactant 3

HCID 10340Sodium Carbonate

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzene

HCID 71204683HCID 71204683, compound

Product 1

HCID 71204729HCID 71204729, compound

Procedure

The title compound (D118) (24 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from methyl 4-((S)-1-((R)-piperidine-2-carboxamido)ethyl)benzoate (D86) (40 mg) and 4-(trifluoromethyl)benzylbromide (0.032 ml). (Na2CO3: 2.5 eq; reaction time: 4 hrs; 60° C.)

Sources & evidence

ORD record: ord-955a4ecdc528406a9c0722eab4f3438f
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09181279B2

Reaction notes

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