HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → (R)-methyl 4-(1-(1-(4-cyanobenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| Reactant | HCID 71204684 | HCID 71204684 | — |
| Product | (R)-methyl 4-(1-(1-(4-cyanobenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate | HCID 71204686 | 74.6% |
Reaction Steps
The title compound (D121) (35 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from (R)-methyl 4-(1-(piperidine-2-carboxamido)cyclopropyl)benzoate (D87) (34 mg) and 4-Cyanobenzylbromide (33 mg). (Na2CO3: 4 eq; reaction time: 18 hrs; 68° C.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181279B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-1c3978dfcf4e487baf2725a52e61e444 |
| Source note | uspto-grants-2015_11 |