Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → HCID 71186634, compound

HRID 712889Notes

Reaction equation

HRID 712889 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]2[CH:13]([C:14](O)=[O:15])[CH:12]3[CH2:17][CH2:18][CH:9]2[CH2:10][CH2:11]3)=[CH:5][CH:4]=1.Cl.[NH2:24][C:25]1([C:28]2[CH:37]=[CH:36][C:31]([C:32]([O:34][CH3:35])=[O:33])=[CH:30][CH:29]=2)[CH2:27][CH2:26]1>>[F:21][C:2]([F:1])([F:22])[C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[CH:13]([C:14]([NH:24][C:25]3([C:28]4[CH:37]=[CH:36][C:31]([C:32]([O:34][CH3:35])=[O:33])=[CH:30][CH:29]=4)[CH2:27][CH2:26]3)=[O:15])[CH:12]3[CH2:17][CH2:18][CH:9]2[CH2:10][CH2:11]3)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 66824369Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 71186564HCID 71186564, compound

Product 1

HCID 71186634HCID 71186634, compoundYield 34.3%

Procedure

The title compound (D156) (12 mg) was prepared according to the general procedure for amides preparation (Method C) starting from 2-(4-(trifluoromethyl)benzyl)-2-azabicyclo[2.2.2]octane-3-carboxylic acid (D111) (22.5 mg) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (18 mg). (Reaction time: 2 hrs; 60° C.)

Workup

  1. custom(Reaction time: 2 hrs; 60° C.)

Sources & evidence

ORD record
ord-f10e65ffe7f147fb855f45bafe8e7612
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

Loading…