Lithium hydroxide, monohydrate → HCID 71186455, compound

HRID 712893Notes

Reaction equation

HRID 712893 reaction equation
[F:1][C@@H:2]1[CH2:6][N:5]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[C@@H:4]([C:18]([NH:20][C@H:21]([C:23]2[CH:32]=[CH:31][C:26]([C:27]([O:29]C)=[O:28])=[CH:25][CH:24]=2)[CH3:22])=[O:19])[CH2:3]1.O[Li:34].O>>[F:1][C@@H:2]1[CH2:6][N:5]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:15])[F:16])[CH:9]=2)[C@@H:4]([C:18]([NH:20][C@H:21]([C:23]2[CH:24]=[CH:25][C:26]([C:27]([O-:29])=[O:28])=[CH:31][CH:32]=2)[CH3:22])=[O:19])[CH2:3]1.[Li+:34]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71204692HCID 71204692, compound

Product 1

HCID 71186455HCID 71186455, compound

Procedure

The title compound (D161) (50 mg) was prepared according to the general procedure for esters hydrolysis (Method A) starting from methyl 4-((S)-1-((2R,4S)-4-fluoro-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxamido)ethyl)benzoate (D160) (67.3 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs).

Sources & evidence

ORD record
ord-0490c04ed5494646a3387d0ae0ef64e5
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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