(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 71204713, compound

HRID 712895Notes

Reaction equation

HRID 712895 reaction equation
[F:1][C:2]1([F:21])[CH2:6][N:5]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[C@@H:4]([C:18]([O-])=[O:19])[CH2:3]1.[Li+].Cl.[NH2:24][C@H:25]([C:27]1[CH:36]=[CH:35][C:30]([C:31]([O:33][CH3:34])=[O:32])=[CH:29][CH:28]=1)[CH3:26]>>[F:21][C:2]1([F:1])[CH2:6][N:5]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:16])([F:17])[F:15])[CH:9]=2)[C@@H:4]([C:18]([NH:24][C@H:25]([C:27]2[CH:36]=[CH:35][C:30]([C:31]([O:33][CH3:34])=[O:32])=[CH:29][CH:28]=2)[CH3:26])=[O:19])[CH2:3]1

Participants

3

Reactant 2

HCID 57462942(S)-Methyl 4-(1-aminoethyl)benzoate hydrochlorideHCID 131733994HCID 131733994, compound

Product 1

HCID 71204713HCID 71204713, compoundYield 48.6%

Procedure

The title compound (D164) (37 mg) was prepared according to the general procedure for amides preparation (Method A) starting from lithium (R)-4,4-difluoro-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate (D115) (51 mg) and (S)-methyl 4-(1-aminoethyl)benzoate hydrochloride (35 mg). (Reaction time: 48 hrs; RT).

Workup

  1. custom(Reaction time: 48 hrs; RT)

Sources & evidence

ORD record
ord-cb1d23f8d77c4b9e94c3dea3b453d7d3
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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