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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712898Generated: October 30, 2026

Lithium Hydroxide → lithium (R)-4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate

https://huagongshe.com/reaction/712898

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
Reactant(R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoateHCID 71204731—
Productlithium (R)-4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoateHCID 71502400—

Reaction Steps

The title compound (E4) (50 mg) was prepared according to the general procedure for esters hydrolysis (Method A) starting from (R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate (D119) (74 mg). (LiOH: 3 eq; Reaction time: 3 hrs; RT)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181279B2
Source datasetuspto-grants-2015_11
ORD IDord-d1dd813d6ef94d228165bfbf08ca6d47
Source noteuspto-grants-2015_11