Lithium Hydroxide → lithium (R)-4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate
Reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C@@H:9]2[C:14]([NH:16][C:17]2([C:20]3[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][CH:21]=3)[CH2:19][CH2:18]2)=[O:15])=[CH:5][CH:4]=1.[Li+:34].[OH-]>>[F:33][C:2]([F:1])([F:32])[C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C@@H:9]2[C:14]([NH:16][C:17]2([C:20]3[CH:21]=[CH:22][C:23]([C:24]([O-:26])=[O:25])=[CH:28][CH:29]=3)[CH2:18][CH2:19]2)=[O:15])=[CH:5][CH:4]=1.[Li+:34]Participants
3
Procedure
The title compound (E4) (50 mg) was prepared according to the general procedure for esters hydrolysis (Method A) starting from (R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate (D119) (74 mg). (LiOH: 3 eq; Reaction time: 3 hrs; RT)
Sources & evidence
- ORD record
- ord-d1dd813d6ef94d228165bfbf08ca6d47
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09181279B2
Reaction notes
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