Lithium hydroxide, monohydrate → HCID 71186475, compound

HRID 712901Notes

Reaction equation

[F:1][C:2]([F:44])([F:43])[C:3]1[CH:42]=[CH:41][C:6]([CH2:7][N:8]2[CH2:15][CH2:14][C:11]3([CH2:13][CH2:12]3)[CH2:10][CH:9]2[C:16]([NH:18][C@H:19]([C:21]2[CH:40]=[CH:39][C:24]([C:25]([O:27]CC3C=CC(C(F)(F)F)=CC=3)=[O:26])=[CH:23][CH:22]=2)[CH3:20])=[O:17])=[CH:5][CH:4]=1.O[Li].O>>[F:43][C:2]([F:1])([F:44])[C:3]1[CH:42]=[CH:41][C:6]([CH2:7][N:8]2[CH2:15][CH2:14][C:11]3([CH2:12][CH2:13]3)[CH2:10][CH:9]2[C:16]([NH:18][C@H:19]([C:21]2[CH:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[CH:39][CH:40]=2)[CH3:20])=[O:17])=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 168937Lithium hydroxide, monohydrate

HCID 89350913HCID 89350913, compound

Product 1

HCID 71186475HCID 71186475, compoundYield 57.3%

Procedure

The title compound (E10) (6.4 mg) was prepared according to the general procedure for esters hydrolysis (Method B) starting from starting from 4-(trifluoromethyl)benzyl 4-((1S)-1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)ethyl)benzoate (D129) (15 mg). (LiOH H2O: 4 eq; Reaction time: 18 hrs)

Sources & evidence

ORD record: ord-9693aee4e8a648a181854e5ce9b2353a
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09181279B2

Reaction notes

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