Lithium hydroxide, monohydrate → HCID 71186249, compound

HRID 712911Notes

Reaction equation

HRID 712911 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:32]=[CH:31][C:6]([CH2:7][N:8]2[CH:14]([C:15]([NH:17][C:18]3([C:21]4[CH:30]=[CH:29][C:24]([C:25]([O:27]C)=[O:26])=[CH:23][CH:22]=4)[CH2:20][CH2:19]3)=[O:16])[CH2:13][CH:12]3[CH:10]([CH2:11]3)[CH2:9]2)=[CH:5][CH:4]=1.O[Li].O>>[F:34][C:2]([F:1])([F:33])[C:3]1[CH:32]=[CH:31][C:6]([CH2:7][N:8]2[CH:14]([C:15]([NH:17][C:18]3([C:21]4[CH:30]=[CH:29][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=4)[CH2:19][CH2:20]3)=[O:16])[CH2:13][CH:12]3[CH:10]([CH2:11]3)[CH2:9]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186489HCID 71186489, compound

Product 1

HCID 71186249HCID 71186249, compoundYield 78%

Procedure

The title compound (E23) (56 mg) was prepared according to the general procedure for esters hydrolysis (Method D) starting from methyl 4-(1-(3-(4-(trifluoromethyl)benzyl)-3-azabicyclo[4.1.0]heptane-4-carboxamido)cyclopropyl)benzoate (D140b) (74 mg). (LiOH H2O: 4 eq; reaction time: 10 hrs)

Sources & evidence

ORD record
ord-0a518ab71c6441319470878620d3a413
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

Loading…