Lithium hydroxide, monohydrate → HCID 71186318, compound

HRID 712912Notes

Reaction equation

HRID 712912 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([CH:30]=[CH:31][CH:32]=1)[CH2:6][N:7]1[CH:13]([C:14]([NH:16][C:17]2([C:20]3[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][CH:21]=3)[CH2:19][CH2:18]2)=[O:15])[CH2:12][CH:11]2[CH:9]([CH2:10]2)[CH2:8]1.O[Li].O>>[F:33][C:2]([F:1])([F:34])[C:3]1[CH:4]=[C:5]([CH:30]=[CH:31][CH:32]=1)[CH2:6][N:7]1[CH:13]([C:14]([NH:16][C:17]2([C:20]3[CH:21]=[CH:22][C:23]([C:24]([OH:26])=[O:25])=[CH:28][CH:29]=3)[CH2:19][CH2:18]2)=[O:15])[CH2:12][CH:11]2[CH:9]([CH2:10]2)[CH2:8]1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186309HCID 71186309, compound

Product 1

HCID 71186318HCID 71186318, compoundYield 62.2%

Procedure

The title compound (E24) (32 mg) was prepared according to the general procedure for esters hydrolysis (Method D) starting from (methyl 4-(1-(3-(3-(trifluoromethyl)benzyl)-3-azabicyclo[4.1.0]heptane-4-carboxamido)cyclopropyl)benzoate (D141) (53 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs)

Sources & evidence

ORD record
ord-deddee5adedc402dbb149e3d10453c01
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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