Lithium hydroxide, monohydrate → HCID 117966850, compound

HRID 712914Notes

Reaction equation

HRID 712914 reaction equation
[F:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[CH2:11][CH2:10][CH2:9][C@@H:8]2[C:12]([NH:14][C@H:15]([C:17]2[CH:26]=[CH:25][C:20]([C:21]([O:23]C)=[O:22])=[CH:19][CH:18]=2)[CH3:16])=[O:13])=[CH:4][CH:3]=1.O[Li:30].O>>[F:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[CH2:11][CH2:10][CH2:9][C@@H:8]2[C:12]([NH:14][C@H:15]([C:17]2[CH:18]=[CH:19][C:20]([C:21]([O-:23])=[O:22])=[CH:25][CH:26]=2)[CH3:16])=[O:13])=[CH:4][CH:3]=1.[Li+:30]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71204733HCID 71204733, compound

Product 1

HCID 117966850HCID 117966850, compound

Procedure

The title compound (E28) (13 mg) was prepared according to the general procedure for esters hydrolysis (Method A) starting from methyl 4-((S)-1-((R)-1-(4-fluorobenzyl)pyrrolidine-2-carboxamido)ethyl)benzoate (D145) (22 mg). (LiOH H2O: 1.2 eq; reaction time: 5 hrs; 70° C.)

Sources & evidence

ORD record
ord-eb825f64af82451bbb7270c9cbb646a4
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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