Lithium hydroxide, monohydrate → HCID 71502472, compound

HRID 712915Notes

Reaction equation

HRID 712915 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[C@@H:12]([C:13]([NH:15][C:16]2([C:19]3[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=3)[CH2:18][CH2:17]2)=[O:14])[CH2:11][CH:10]2[CH:8]1[CH2:9]2.O[Li].O>>[F:32][C:2]([F:1])([F:33])[C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[C@@H:12]([C:13]([NH:15][C:16]2([C:19]3[CH:20]=[CH:21][C:22]([C:23]([OH:25])=[O:24])=[CH:27][CH:28]=3)[CH2:18][CH2:17]2)=[O:14])[CH2:11][C@@H:10]2[C@H:8]1[CH2:9]2

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 117966919HCID 117966919, compound

Product 1

HCID 71502472HCID 71502472, compoundYield 89.4%

Procedure

The title compound (E29) (52 mg) was prepared according to the general procedure for esters hydrolysis (Method D) starting from methyl 4-(1-((3R)-2-(3-(trifluoromethyl)benzyl)-2-azabicyclo[3.1.0]hexane-3-carboxamido)cyclopropyl)benzoate (D146) (60 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs)

Sources & evidence

ORD record
ord-89733c763eec444b99840855d6ca5971
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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