Lithium hydroxide, monohydrate → HCID 71204677, compound

HRID 712917Notes

Reaction equation

HRID 712917 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:30]=[CH:29][C:6]([CH2:7][N:8]2[C@@H:13]([C:14]([NH:16][C@H:17]([C:19]3[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=3)[CH3:18])=[O:15])[CH2:12][CH:11]3[CH:9]2[CH2:10]3)=[CH:5][CH:4]=1.O[Li].O>>[F:31][C:2]([F:1])([F:32])[C:3]1[CH:30]=[CH:29][C:6]([CH2:7][N:8]2[C@@H:13]([C:14]([NH:16][C@H:17]([C:19]3[CH:20]=[CH:21][C:22]([C:23]([OH:25])=[O:24])=[CH:27][CH:28]=3)[CH3:18])=[O:15])[CH2:12][CH:11]3[CH:9]2[CH2:10]3)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71204658HCID 71204658, compound

Product 1

HCID 71204677HCID 71204677, compoundYield 90.7%

Procedure

The title compound (E32) (12.3 mg) was prepared according to the general procedure for esters hydrolysis (Method C) starting from methyl 4-((1S)-1-((3R)-2-(4-(trifluoromethyl)benzyl)-2-azabicyclo[3.1.0]hexane-3-carboxamido)ethyl)benzoate (D149) (14 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs)

Sources & evidence

ORD record
ord-35c3efdc0a864373bc5f782753240617
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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