Lithium hydroxide, monohydrate → HCID 71186244, compound

HRID 712922Notes

Reaction equation

HRID 712922 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:32]=[CH:31][C:6]([CH2:7][N:8]2[CH:13]([C:14]([NH:16][C@H:17]([C:19]3[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=3)[CH3:18])=[O:15])[CH:12]3[CH2:29][CH2:30][CH:9]2[CH2:10][CH2:11]3)=[CH:5][CH:4]=1.O[Li].O>>[F:33][C:2]([F:1])([F:34])[C:3]1[CH:32]=[CH:31][C:6]([CH2:7][N:8]2[CH:13]([C:14]([NH:16][C@H:17]([C:19]3[CH:28]=[CH:27][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=3)[CH3:18])=[O:15])[CH:12]3[CH2:11][CH2:10][CH:9]2[CH2:30][CH2:29]3)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186480HCID 71186480, compound

Product 1

HCID 71186244HCID 71186244, compoundYield 100.7%

Procedure

The title compound (E39) (11.04 mg) was prepared according to the general procedure for esters hydrolysis (Method C) starting from methyl 4-((1S)-1-(2-(4-(trifluoromethyl)benzyl)-2-azabicyclo[2.2.2]octane-3-carboxamido)ethyl)benzoate (D155) (11.3 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs)

Sources & evidence

ORD record
ord-951096a2d5c9412599ae61cc034d9cc6
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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