Lithium hydroxide, monohydrate → HCID 71186354, compound

HRID 712923Notes

Reaction equation

HRID 712923 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:33]=[CH:32][C:6]([CH2:7][N:8]2[CH:13]([C:14]([NH:16][C:17]3([C:20]4[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][CH:21]=4)[CH2:19][CH2:18]3)=[O:15])[CH:12]3[CH2:30][CH2:31][CH:9]2[CH2:10][CH2:11]3)=[CH:5][CH:4]=1.O[Li].O>>[F:35][C:2]([F:1])([F:34])[C:3]1[CH:33]=[CH:32][C:6]([CH2:7][N:8]2[CH:13]([C:14]([NH:16][C:17]3([C:20]4[CH:21]=[CH:22][C:23]([C:24]([OH:26])=[O:25])=[CH:28][CH:29]=4)[CH2:18][CH2:19]3)=[O:15])[CH:12]3[CH2:30][CH2:31][CH:9]2[CH2:10][CH2:11]3)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186634HCID 71186634, compound

Product 1

HCID 71186354HCID 71186354, compoundYield 108.8%

Procedure

The title compound (E40) (8.03 mg) was prepared according to the general procedure for esters hydrolysis (Method C) starting from methyl 4-(1-(2-(4-(trifluoromethyl)benzyl)-2-azabicyclo[2.2.2]octane-3-carboxamido)cyclopropyl)benzoate (D156) (7.6 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs)

Sources & evidence

ORD record
ord-2094ecd641bd48a482972d021794dbcb
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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