反应详情

温度

75 °C

[8-Benzyl-10-(1-hydroxy-1-methyl-ethyl)-11-oxa-3,8-diazaspiro[5.5]undecan-3-yl]-(4-isopropoxy-3-methyl-phenyl)methanone (75 mg, 0.16 mmol) was dissolved in ethanol (3 mL) and Pd (8 mg, 0.008 mmol) and ammonium formate (50 mg, 0.80 mmol) were added and the reaction mixture was heated at 75° C. for 30 minutes. The reaction mixture was filtered, concentrated in vacuo, diluted with ethyl acetate, washed with 3M NaOH, dried over MgSO4, filtered and concentrated in vacuo to give (2-(2-hydroxypropan-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)(4-isopropoxy-3-methylphenyl)methanone (60 mg, 94%). ESI-MS m/z calc. 390.3. found 391.5 (M+1)+; Retention time: 1.27 minutes (3 min run).

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated in vacuo
3. additiondiluted with ethyl acetate
4. washwashed with 3M NaOH
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated in vacuo