反应详情

A solution of (9,9-dimethyl-11-oxa-3,8-diazaspiro[5.5]undecan-3-yl)-(4-isopropoxy-3-methyl-phenyl)methanone (11.0 mg, 0.0305 mmol), potassium carbonate (4.2 mg, 0.031 mmol) and 2-chloropyrimidine (3.7 mg, 0.031 mmol) in DMSO (90 μL) was heated at 90° C. for 2 h. The reaction was filtered and purified by HPLC (1-99% CH3CN/5 mM HCl) to provide (3,3-dimethyl-4-(pyrimidin-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)(4-isopropoxy-3-methylphenyl)methanone hydrochloride (6.0 mg, 0.012 mmol, 38%). ESI-MS m/z calc. 438.3. found 439.3 (M+1)+; Retention time: 1.92 minutes (3 min run).

1. filtrationThe reaction was filtered
2. custompurified by HPLC (1-99% CH3CN/5 mM HCl)