Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Piperidinecarboxylic acid, 4-[(R)-(2,4-difluorophenyl)fluoromethyl]-, 1,1-dimethylethyl ester | HCID 118159257 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Hydrochloric Acid | HCID 313 | 93% |
| Product | HCID 90038278 | HCID 90038278 | — |
Reaction Steps
(R)-tert-butyl 4-((2,4-difluorophenyl)fluoromethyl)piperidine-1-carboxylate (2.8 g, 8.50 mmol) was dissolved in EtOAc (20 mL) and HCl (4 M in EtOAc, 21 mL) was added. The reaction mixture was stirred at 23° C. for 2 h. Evaporation of the solvent gave the title compound as its HCl salt (2.1 g, 93%). ESI-MS m/z [M+H]+ 229.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09181249B2 |
|---|
| Source dataset | uspto-grants-2015_11 |
|---|
| ORD ID | ord-e31a0a151fef4e8b8ea313492b6963dd |
|---|
| Source note | uspto-grants-2015_11 |
|---|
