Hydrochloric Acid → Hydrochloric Acid

HRID 713186Notes

Reaction equation

HRID 713186 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@H:9]([F:23])[CH:10]1[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12][CH2:11]1.[ClH:24]>CCOC(C)=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]([F:23])[CH:10]1[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:21])([CH3:20])[CH3:22])=[O:17])[CH2:12][CH2:11]1.[ClH:24]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 1181592571-Piperidinecarboxylic acid, 4-[(R)-(2,4-difluorophenyl)fluoromethyl]-, 1,1-dimethylethyl ester

Product 2

HCID 313Hydrochloric AcidYield 93%HCID 90038278HCID 90038278, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
23 °C

Procedure

(R)-tert-butyl 4-((2,4-difluorophenyl)fluoromethyl)piperidine-1-carboxylate (2.8 g, 8.50 mmol) was dissolved in EtOAc (20 mL) and HCl (4 M in EtOAc, 21 mL) was added. The reaction mixture was stirred at 23° C. for 2 h. Evaporation of the solvent gave the title compound as its HCl salt (2.1 g, 93%). ESI-MS m/z [M+H]+ 229.9.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-e31a0a151fef4e8b8ea313492b6963dd
Source dataset
uspto-grants-2015_11
Patent number
US09181249B2

Reaction notes

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