Hydrochloric Acid → HCID 13825032, compound

HRID 713189Notes

Reaction equation

HRID 713189 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([CH:11]1[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1)(=[O:10])=[O:9].Cl>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)(=[O:9])=[O:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118159133HCID 118159133, compound

Product 1

HCID 13825032HCID 13825032, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of tert-butyl 4-((2-fluorophenyl)sulfonyl)piperidine-1-carboxylate (1.31 g, 3.82 mmol) in dioxane (12.7 mL) at room temperature was treated with 4M HCl in dioxane (9.55 ml, 38.2 mmol). The reaction mixture was allowed to stir at room temperature overnight. The reaction mixture was concentrated under reduced pressure. The resulting white solid was triturated with hexanes, filtered, collected, and lyophilized overnight to give the title compound, as its HCl salt, as a white solid (815.1 mg, 76%). ESI-MS m/z [M+H]+243.95.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe resulting white solid was triturated with hexanes
  3. filtrationfiltered
  4. customcollected
  5. waitlyophilized overnight

Sources & evidence

ORD record
ord-e784ccd5cc964131a76013787026fc16
Source dataset
uspto-grants-2015_11
Patent number
US09181249B2

Reaction notes

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