Hydrochloric Acid → Hydrochloric Acid

HRID 713195Notes

Reaction equation

HRID 713195 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([S:8]([CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[ClH:24]>O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([S:8]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[ClH:24]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 118159247HCID 118159247, compound

Product 2

HCID 313Hydrochloric AcidYield 726%HCID 68212053HCID 68212053, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
23 °C

Procedure

To a solution of tert-butyl 4-((3-fluorophenyl)sulfonyl)piperidine-1-carboxylate (756 mg, 2.201 mmol) in dioxane (5.0 mL) was added HCl (4 M in dioxane, 5.50 mL, 22.01 mmol) at 23° C. The reaction was stirred at 23° C. for 21 h to furnish a white suspension. The resulting solid was filtered, rinsed with dioxane and dried in vacuo to give the title compound as its HCl salt (582.6 mg, 95%) as a white solid. ESI-MS m/z [M+H]+ 243.9.

Workup

  1. customto furnish a white suspension
  2. filtrationThe resulting solid was filtered
  3. washrinsed with dioxane
  4. customdried in vacuo

Sources & evidence

ORD record
ord-32e2b39d64994252a2f77b3e01f263b6
Source dataset
uspto-grants-2015_11
Patent number
US09181249B2

Reaction notes

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