Hydrochloric Acid → Hydrochloric Acid

HRID 713198Notes

Reaction equation

HRID 713198 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[ClH:24]>O1CCOCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)(=[O:9])=[O:10])=[CH:6][CH:7]=1.[ClH:24]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11024351tert-Butyl 4-(4-fluorobenzene-1-sulfonyl)piperidine-1-carboxylate

Product 2

HCID 313Hydrochloric AcidYield 721.8%HCID 11032089150221-22-0

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 4-((4-fluorophenyl)sulfonyl)piperidine-1-carboxylate (32.7 mg, 0.095 mmol) in dioxane (238 μL) at room temperature was treated with HCl (4 M in dioxane, 190 μL, 0.762 mmol) and the resulting reaction mixture was stirred for 4 h. The solvent was removed to give the title compound as its HCl salt (25 mg, 94%) as a white solid. ESI-MS m/z [M+H]+ 243.95.

Workup

  1. customthe resulting reaction mixture
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-f9be12c525b24531b2e1166e7b315aec
Source dataset
uspto-grants-2015_11
Patent number
US09181249B2

Reaction notes

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