反应详情

To a stirred solution of NaH (11.96 g, 299 mmol) in 260 mL DMF at 0° C. was sequentially added 2-(chloromethyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one (20 g, 100 mmol) and tert-butyl cyclopropylmethylcarbamate (17.07 g, 100 mmol) in small portions in order to maintain the internal temperature at or below 5° C. The reaction mixture was allowed to warm to room temperature slowly with continued stirring over 12 h. The reaction was cooled to 0 C and water was added slowly (˜250 mL total). The reaction mixture was concentrated in vacuo, taken up in ethyl acetate, filtered and concentrated to a red oil. The material was purified on a pad of silica gel, loading with 20% ethyl acetate in heptanes and eluting with 100% ethyl acetate via a sharp gradient. The title compound was obtained as an off-white solid (20.79 g).

1. customat 0° C.
2. temperatureto maintain the internal temperature at or below 5° C
3. additionwas added slowly (˜250 mL total)
4. concentrationThe reaction mixture was concentrated in vacuo
5. filtrationfiltered
6. concentrationconcentrated to a red oil
7. customThe material was purified on a pad of silica gel, loading with 20% ethyl acetate in heptanes
8. washeluting with 100% ethyl acetate via a sharp gradient