Triethylamine → HCID 136627253, compound

HRID 713397Notes

Reaction equation

HRID 713397 reaction equation
O=[C:2]1[CH2:7][CH2:6][O:5][CH2:4][CH:3]1[C:8]([O:10]C)=O.Cl.[Cl:13][CH:14]([CH3:18])[C:15](=[NH:17])[NH2:16].C(N(CC)CC)C>>[Cl:13][CH:14]([C:15]1[NH:17][C:8](=[O:10])[C:3]2[CH2:4][O:5][CH2:6][CH2:7][C:2]=2[N:16]=1)[CH3:18]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 14666555Methyl 4-oxooxane-3-carboxylateHCID 71755989120883-73-0

Product 1

HCID 136627253HCID 136627253, compoundYield 103.5%

Procedure

A mixture of methyl 4-oxotetrahydro-2H-pyran-3-carboxylate (1.0 g, 6.3 mmol), 2-chloropropanimidamide hydrochloride (0.9 g, 6.3 mmol), and triethylamine (3.52 mL, 25.4 mmol) was stirred at ambient temperature for 24 h. The mixture was concentrated in vacuo to give the title compound (1.4 g), which was used directly to the next step without further purification. MS m/z 215.2 (M+1), retention time=1.27 min.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-e8089be350b243afbf5cd5390485c5fb
Source dataset
uspto-grants-2015_11
Patent number
US09181266B2

Reaction notes

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