Water → HCID 136627260, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(1-chloroethyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one (270 mg, 1.3 mmol) in methanol (1 mL) was added methylamine in water (1.1 mL, 13 mmol, 40%). The mixture was heated via microwave at 110° C. for 10 min., concentrated in vacuo and purified via reverse phase chromatography (Acetonitrile:water) to provide the title compound (260 mg). MS m/z 210.3 (M+1), retention time=0.54 min.

Provenance & Evidence