Water → HCID 136627260, compound

HRID 713398Notes

Reaction equation

HRID 713398 reaction equation
Cl[CH:2]([C:4]1[NH:5][C:6](=[O:14])[C:7]2[CH2:13][O:12][CH2:11][CH2:10][C:8]=2[N:9]=1)[CH3:3].[CH3:15][NH2:16].O>CO>[CH3:15][NH:16][CH:2]([C:4]1[NH:5][C:6](=[O:14])[C:7]2[CH2:13][O:12][CH2:11][CH2:10][C:8]=2[N:9]=1)[CH3:3]

Participants

5

Reactant 3

HCID 962WaterHCID 6329MethylamineHCID 136627253HCID 136627253, compound

Product 1

HCID 136627260HCID 136627260, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
110 °C

Procedure

To a solution of 2-(1-chloroethyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one (270 mg, 1.3 mmol) in methanol (1 mL) was added methylamine in water (1.1 mL, 13 mmol, 40%). The mixture was heated via microwave at 110° C. for 10 min., concentrated in vacuo and purified via reverse phase chromatography (Acetonitrile:water) to provide the title compound (260 mg). MS m/z 210.3 (M+1), retention time=0.54 min.

Workup

  1. concentrationconcentrated in vacuo
  2. custompurified via reverse phase chromatography (Acetonitrile:water)

Sources & evidence

ORD record
ord-ab4e9604491247bfbfce2519bb46d736
Source dataset
uspto-grants-2015_11
Patent number
US09181266B2

Reaction notes

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