反应详情

温度

-78 °C

A solution of 1-[4-(6-fluoro-1H-indazol-3-yl)-piperidin-1-yl]-ethanone (0.60 g, 2.3 mmol) in 4 mL of 6 N HCl was stirred at reflux for 6 hours. It was frozen at −78° C. and lyophilized for 24 hours to yield the title compound as a white solid (0.61 g, 2.7 mmol, >99% yield). MS (ESI) m/z 219.9 (M+H+); HPLC (Novapak 150×3.9 mm C-18 column: mobile phase: 35-90% acetonitrile/water with 0.1% TFA, at 2 mL/min over 2 min.) t 0.96 min.

1. temperatureat reflux for 6 hours