反应详情

To a solution of 4-(2-trifluoromethoxy-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester (0.5 g, 1.34 mmol, 1 eq.) in 1 mL of dichloromethane was added 10 mL of 4 N HCl in dioxane and stirred at room temperature overnight. After 18 h, the reaction mixture was concentrated and triturated with diethyl ether to give the title compound as a white solid (0.365 g, 88%). Exact mass calculated for C13H13F3N1O2 274.1. MS (ESI) m/z 274.3 (M+H)+.

1. waitAfter 18 h
2. concentrationthe reaction mixture was concentrated
3. customtriturated with diethyl ether