Hydrochloric Acid → 2-(4-(4-Ethoxybenzoyl)piperidin-1-yl)acetic acid

HRID 713426Notes

Reaction equation

F[C:2]1[CH:19]=[CH:18][C:5]([C:6]([CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]([OH:17])=[O:16])[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[OH-].[Na+].Cl.[CH2:23]([OH:25])[CH3:24]>O>[CH2:23]([O:25][C:2]1[CH:19]=[CH:18][C:5]([C:6]([CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]([OH:17])=[O:16])[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1)[CH3:24]

Participants

Conditions

Temperature: 80 °C

Procedure

To a solution of 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid (600 mg, 2.26 mmol) in ethanol (20 mL) was added sodium hydroxide (400 mg, 10.0 mmol) in water (2 mL) and heated at 80° C. for 24 h. The reaction mixture was neutralized with aqueous hydrochloric acid (1 N), the solvent was evaporated under reduced pressure and used to the next step directly. MS m/z 292.3 (M+1), retention time=0.99 min.

Workup

customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record: ord-89da0686f05448cf839d40e368a76797
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09181266B2

Reaction notes

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