Hydrochloric Acid → HCID 67009156, compound

HRID 713441Notes

Reaction equation

HRID 713441 reaction equation
C([O:5][C:6](=[O:18])[CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9]1)(C)(C)C.Cl>ClCCl.O1CCOCC1>[CH3:17][O:16][C:14]([CH:11]1[CH2:10][CH2:9][N:8]([CH2:7][C:6]([OH:18])=[O:5])[CH2:13][CH2:12]1)=[O:15]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 53742937HCID 53742937, compound

Product 1

HCID 67009156HCID 67009156, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of methyl 1-(2-tert-butoxy-2-oxoethyl)piperidine-4-carboxylate (3.0 g, 12 mmol) in dichloromethane (9 mL) was added hydrochloric acid in 1,4-dioxane (4 M) and stirred at ambient temperature for 24 h. The final product was formed as a white solid, which was washed with ether and filtered (2.3 g). 1H NMR (400 MHz, DMSO-d6) δ 4.09 (s, 2H), 3.64 (s, 3H), 3.46 (br. s., 2H), 3.11 (br. s., 2H), 2.67 (br. s., 1H), 1.82-2.12 (m, 4H)

Sources & evidence

ORD record
ord-149cc85f53b44e558ca3ae5339253e9d
Source dataset
uspto-grants-2015_11
Patent number
US09181266B2

Reaction notes

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