HCID 67009156, compound → HCID 136627229, compound

HRID 713442Notes

Reaction equation

HRID 713442 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]([OH:14])=O)[CH2:7][CH2:6]1)=[O:4].[NH2:15][CH2:16][C:17]1[NH:18][C:19](=[O:27])[C:20]2[CH2:26][O:25][CH2:24][CH2:23][C:21]=2[N:22]=1>>[O:14]=[C:12]([NH:15][CH2:16][C:17]1[NH:18][C:19](=[O:27])[C:20]2[CH2:26][O:25][CH2:24][CH2:23][C:21]=2[N:22]=1)[CH2:11][N:8]1[CH2:7][CH2:6][CH:5]([C:3]([O:2][CH3:1])=[O:4])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 67009156HCID 67009156, compoundHCID 1357418942-(Aminomethyl)-7,8-dihydro-3H-pyrano[4,3-D]pyrimidin-4(5H)-one

Product 1

HCID 136627229HCID 136627229, compoundYield 39.7%

Procedure

The title compound (1.2 g) was prepared according the general procedure of Example 1 from 2-(4-(methoxycarbonyl)piperidin-1-yl)acetic acid (2.2 g, 11 mmol) and 2-aminomethyl-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one (1.5 g, 8.3 mmol). MS m/z 365.3 (M+1), retention time=1.46 min.

Sources & evidence

ORD record
ord-d89ea89eb27241a0a9a20fca18e78e67
Source dataset
uspto-grants-2015_11
Patent number
US09181266B2

Reaction notes

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