反应详情

To a solution of 4-(3-chloro-4-methoxy-benzoyl)-piperidine-1-carboxylic acid tert-butylester (1.1 g, 3.1 mmol) in 20 mL of 6N HCl, the reaction mixture was stirred at ambient temperature for 18 hours, then solvent was removed by reduced pressure to yield the title product (0.75 g, 2.8 mmol). MS (ESI) m/z 254.0 (M+H+); HPLC (Novapak 150×3.9 mm C-18 column: mobile phase: 35-90% acetonitrile/water with 0.1% TFA, at 2 mL/min over 2 min.) t 1.39 min.

1. customsolvent was removed by reduced pressure