反应详情

温度

40 °C

To a solution of [4-(4-benzyloxy-benzoyl)-piperidin-1-yl]-acetic acid ethyl ester (180 mg, 0.47 mmol) in water (2 mL) and ethanol (2 mL) was added a 4N solution of NaOH (0.24 mL, 0.94 mmol). The reaction was heated up to 40° C. for 3 hours. The reaction was acidified to pH 3 using 1N HCl, then the solvent was then evaporated under vacuum to afford the crude title compound (260 mg). LRMS m/z: ES+=354.4 (M+H), retention time 1.11.

1. customthe solvent was then evaporated under vacuum