Thionyl Chloride → 4-(Diethylamino)benzoyl chloride

HRID 713543Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 713543
S(Cl)([Cl:3])=O.[CH2:5]([N:7]([CH2:17][CH3:18])[C:8]1[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=1)[CH3:6]>C1C=CC=CC=1>[CH2:5]([N:7]([CH2:17][CH3:18])[C:8]1[CH:16]=[CH:15][C:11]([C:12]([Cl:3])=[O:13])=[CH:10][CH:9]=1)[CH3:6]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 79480Benzoic acid, 4-(diethylamino)-

Produkt 1

HCID 127070214-(Diethylamino)benzoyl chlorideAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

First, thionyl chloride was added dropwise to a benzene solution (20 mL) containing 0.96 g (5 mmol) of 4-(diethylamino)benzoic acid (a compound (10-2) in the following reaction formula) and was allowed to react at room temperature in a nitrogen atmosphere, yielding 4-(diethylamino)benzoic acid chloride (a compound (10-3) in the following reaction formula, 4.65 mmol, yield 93%).

Aufarbeitung

  1. customto react at room temperature in a nitrogen atmosphere

Quellen und Nachweise

ORD-Eintrag
ord-0e7ec860f1834fab876f9a62ca64ef3e
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09182632B2

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