反应详情

First, thionyl chloride was added dropwise to a benzene solution (20 mL) containing 0.96 g (5 mmol) of 4-(diethylamino)benzoic acid (a compound (10-2) in the following reaction formula) and was allowed to react at room temperature in a nitrogen atmosphere, yielding 4-(diethylamino)benzoic acid chloride (a compound (10-3) in the following reaction formula, 4.65 mmol, yield 93%).

1. customto react at room temperature in a nitrogen atmosphere