Ammonia → 2,3,6-Trifluoro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)phenol

HRID 713773Notes

Reaction equation

HRID 713773 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[F:11][C:12]1[C:20]([OH:21])=[C:19]([F:22])[C:18]([F:23])=[CH:17][C:13]=1[C:14](O)=O.N>>[F:22][C:19]1[C:18]([F:23])=[CH:17][C:13]([C:14]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[N:10]=2)=[C:12]([F:11])[C:20]=1[OH:21]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 27342702,4,5-Trifluoro-3-hydroxybenzoic Acid

Product 1

HCID 866212562,3,6-Trifluoro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)phenol

Procedure

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 2,4,5-trifluoro-3-hydroxybenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.63-7.76 (m, 2H), 8.44 (dt, J=7.9, 2.0 Hz, 1H), 8.83 (dd, J=4.8, 1.6 Hz, 1H), 9.25 (d, J=1.6 Hz, 1H) ppm; MS (DCl/NH3) m/z 294 (M+H)+.

Sources & evidence

ORD record
ord-bc431ce4f2b64083a1813de949aeaede
Source dataset
uspto-grants-2015_11
Patent number
US09186407B2

Reaction notes

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