HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2,3,6-Trifluoro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N-Hydroxynicotinimidamide | HCID 308113 | — |
| Reactant | 2,4,5-Trifluoro-3-hydroxybenzoic Acid | HCID 2734270 | — |
| Product | 2,3,6-Trifluoro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)phenol | HCID 86621256 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 2,4,5-trifluoro-3-hydroxybenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.63-7.76 (m, 2H), 8.44 (dt, J=7.9, 2.0 Hz, 1H), 8.83 (dd, J=4.8, 1.6 Hz, 1H), 9.25 (d, J=1.6 Hz, 1H) ppm; MS (DCl/NH3) m/z 294 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09186407B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-bc431ce4f2b64083a1813de949aeaede |
| Source note | uspto-grants-2015_11 |