反应详情

A solution of 3-fluoro-4-(trifluoromethyl)benzaldehyde (1.40 g, 7.07 mmol) and p-toluenesulfonylmethyl isocyanide (1.53 g, 7.68 mmol; TosMIC) in MeOH (100 mL) was treated with potassium carbonate (1.97 g, 14.14 mmol) and the suspension heated to reflux for 14 h. After being cooled to room temperature, the solvent was removed under reduced pressure and the crude product triturated with water at 0° C. (2×25 mL). The slightly orange precipitate was collected by filtration and dried under vacuum (4.46 g, 92%). MS: 232.0 (M+H)+.

1. temperaturethe suspension heated
2. temperatureto reflux for 14 h
3. customthe solvent was removed under reduced pressure
4. customthe crude product triturated with water at 0° C. (2×25 mL)
5. filtrationThe slightly orange precipitate was collected by filtration
6. customdried under vacuum (4.46 g, 92%)