HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Fluoro-4-trifluoromethyl-phenyl)-5,6-dihydro-[2]pyrindin-7-one → 4-(4-Trifluoromethyl-phenyl)-5,6-dihydro-[2]pyrindin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Fluoro-4-trifluoromethyl-phenyl)-5,6-dihydro-[2]pyrindin-7-one | HCID 89846288 | — |
| Reactant | 4-(4-Trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindine | HCID 89846308 | — |
| Product | 4-(4-Trifluoromethyl-phenyl)-5,6-dihydro-[2]pyrindin-7-one | HCID 89846168 | 24% |
Reaction Steps
In analogy to the procedure described for the preparation of 4-(3-fluoro-4-trifluoromethyl-phenyl)-5,6-dihydro-[2]pyrindin-7-one (intermediate A-14 [C1]), replacing 4-(3-fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindine with 4-(4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindine. The title compound was obtained as a light brown oil in 24% yield. MS: 278.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-3ec7481f8f634253aaf8f5182546f799 |
| Source note | uspto-grants-2015_11 |