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Isobutyryl chloride → (rac)-N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isobutyryl chloride | HCID 62325 | — |
| 反応物 | 4-(8-Amino-5,6,7,8-tetrahydro-4-isoquinolinyl)benzonitrile | HCID 71811360 | — |
| 生成物 | (rac)-N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide | HCID 89846366 | 63% |
反応手順
In analogy to the procedure described for the preparation of example 8, (rac)-4-(8-amino-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile (example 1) was reacted with isobutyryl chloride to give the title compound as a off-white powder in 63% yield. MS: 320.2 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09187429B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-598b447532c24df98b83477da5213970 |
| 出典メモ | uspto-grants-2015_11 |