HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → (rac)-N-(4-(3-Chloro-4-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) | HCID 2734660 | — |
| Reactant | N-(4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide | HCID 86685953 | — |
| Product | (rac)-N-(4-(3-Chloro-4-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide | HCID 71811409 | 74% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (rac)-N-(4-bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide (intermediate A-1) was reacted with 3-chloro-4-fluorophenylboronic acid to give the title compound as light grey foam in 74% yield. MS: 333.1 (M+H+, 1Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-c18eef64617948bf8c2e7c79f11c1e68 |
| Source note | uspto-grants-2015_11 |