(4-Fluoro-3-methylphenyl)boronic acid → HCID 71811645, compound

HRID 714083Notes

Reaction equation

HRID 714083 reaction equation
Br[C:2]1[C:3]2[CH2:10][CH2:9][CH:8]([NH:11][C:12](=[O:15])[CH2:13][CH3:14])[C:4]=2[CH:5]=[N:6][CH:7]=1.[F:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][C:18]=1[CH3:26]>>[F:16][C:17]1[CH:22]=[CH:21][C:20]([C:2]2[C:3]3[CH2:10][CH2:9][CH:8]([NH:11][C:12](=[O:15])[CH2:13][CH3:14])[C:4]=3[CH:5]=[N:6][CH:7]=2)=[CH:19][C:18]=1[CH3:26]

Participants

3

Reactant 2

HCID 2774580(4-Fluoro-3-methylphenyl)boronic acidHCID 86685956N-(4-Bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide

Product 1

HCID 71811645HCID 71811645, compoundYield 86%

Procedure

In analogy to the procedure described for the preparation of example 1, (rac)-N-(4-bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide (intermediate A-4) was reacted with 4-fluoro-3-methylphenylboronic acid to give the title compound as grey solid in 86% yield. MS: 299.2 (M+H+).

Sources & evidence

ORD record
ord-be60839dab9542819b0f4fa9e691f7c9
Source dataset
uspto-grants-2015_11
Patent number
US09187429B2

Reaction notes

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