HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → (+)-(R)-N-(4-(2-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | (+)-(R)-4-(2-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-amine | HCID 71811573 | — |
| Product | (+)-(R)-N-(4-(2-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide | HCID 71811571 | 90% |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-4 [D], (+)-(R)-4-(2-fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-amine (example 74) and acetic acid gave the title compound as off-white amorphous solid in 90% yield. MS: 353.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-997274724d804e6c9af73a33952d2779 |
| Source note | uspto-grants-2015_11 |