Hydrochloric Acid → HCID 117676275, compound

HRID 714122Notes

Reaction equation

HRID 714122 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[C:10]([O:12][C:13]1[CH:14]=[CH:15][C:16]([F:23])=[C:17]([CH:22]=1)[C:18]([O:20]C)=[O:19])=[N:9][NH:8][C:7]2=[O:24].Cl>[OH-].[K+]>[F:23][C:16]1[CH:15]=[CH:14][C:13]([O:12][C:10]2[C:11]3[C:6](=[CH:5][CH:4]=[CH:3][C:2]=3[Cl:1])[C:7](=[O:24])[NH:8][N:9]=2)=[CH:22][C:17]=1[C:18]([OH:20])=[O:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117676244HCID 117676244, compound

Product 1

HCID 117676275HCID 117676275, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

Methyl 5-((8-chloro-4-oxo-3,4-dihydrophthalazin-1-yl)oxy)-2-fluorobenzoate (5e) (1 g, 2.87 mmol) was dissolved in 1M potassium hydroxide solution, stirred for two hours at room temperature, and then concentrated hydrochloric acid was added dropwise to adjust the reaction mixture pH=3, stirred for two hours at room temperature, and filtrated to give 2-fluoro-5-(8-chloro-4-oxo-3,4-dihydro-phthalazin-1-yl-oxyl)benzoic acid (5f), 900 mg white solid (yield 90%). ESI-MS m/z: calculated for 334.02. found 357.10 [M+Na]+.

Workup

  1. stirringstirred for two hours at room temperature
  2. filtrationfiltrated

Sources & evidence

ORD record
ord-074b1bd5268c4f8c9f4d360fb7648d5e
Source dataset
uspto-grants-2015_11
Patent number
US09187430B2

Reaction notes

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