Trifluoroacetic acid → 1-(Cyclopropylcarbonyl)piperazine

HRID 714125Notes

Reaction equation

HRID 714125 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([CH:16]2[CH2:18][CH2:17]2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH:16]1([C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:15])[CH2:17][CH2:18]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 968936Tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate

Product 1

HCID 20642351-(Cyclopropylcarbonyl)piperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-Tertbutoxycarbonyl-4-(cyclopropanecarbonyl) piperazine (254 mg, 1 mmol) was dissolved in dichloromethane, and then trifluoroacetic acid (1.5 mL) was added. The reaction mixture was stirred at room temperature until completed, and then washed with saturated sodium bicarbonate solution for three times. The organic phases were concentrated. N-(cyclopropanecarbonyl) piperazine was obtained for use.

Workup

  1. washwashed with saturated sodium bicarbonate solution for three times
  2. concentrationThe organic phases were concentrated

Sources & evidence

ORD record
ord-8bdec8020d2c486eb76a4357b2416d2f
Source dataset
uspto-grants-2015_11
Patent number
US09187430B2

Reaction notes

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