反应详情

In a flame dried round-bottomed flask equipped with a magnetic stir bar, a suspension of 1-benzyl-3,3-difluoropiperidin-4-ol (1.73 g, 7.62 mmol) and Pd(OH)2 (20% Pd, 107 mg) in dry EtOH (50 mL) was stirred at rt under a H2 atmospheric pressure until completion of the reaction. The mixture was then filtered, washed with EA/EtOH, and the filtrate concentrated under reduced pressure to give the title compound as a beige solid.

1. customIn a flame dried round-bottomed flask equipped with a magnetic stir bar
2. customuntil completion of the reaction
3. filtrationThe mixture was then filtered
4. washwashed with EA/EtOH
5. concentrationthe filtrate concentrated under reduced pressure