Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitrogen | HCID 947 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromobutanol | HCID 118388 | — |
| Reactant | (S)-3-fluoropyrrolidine | HCID 7016277 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 69672155 | HCID 69672155 | — |
Reaction Steps
In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a suspension of 4-bromo-1-butanol (187 mg, 1.20 mmol), (S)-3-fluoropyrrolidine (186 mg, 1.44 mmol) and K2CO3 (392 mg, 1.56 mmol) in CH3CN (8 mL) was heated to 100° C. under microwave irradiations for 25 min. The mixture was then filtered and the solvent removed under reduced pressure to give the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09187435B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-8a0aa754dfd9463790c2bf7de9e56c38 |
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| Source note | uspto-grants-2015_11 |
|---|