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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 714224Generated: October 29, 2026

Nitrogen → HCID 69672155, compound

https://huagongshe.com/reaction/714224

Reaction equation

Participants

RoleNameHCIDCharge
ReactantNitrogenHCID 947—
ReactantPotassium CarbonateHCID 11430—
Reactant4-BromobutanolHCID 118388—
Reactant(S)-3-fluoropyrrolidineHCID 7016277—
SolventAcetonitrileHCID 6342—
ProductHCID 69672155HCID 69672155—

Reaction Conditions

Temperature100 °C

Reaction Steps

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a suspension of 4-bromo-1-butanol (187 mg, 1.20 mmol), (S)-3-fluoropyrrolidine (186 mg, 1.44 mmol) and K2CO3 (392 mg, 1.56 mmol) in CH3CN (8 mL) was heated to 100° C. under microwave irradiations for 25 min. The mixture was then filtered and the solvent removed under reduced pressure to give the title compound as a colorless oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187435B2
Source datasetuspto-grants-2015_11
ORD IDord-8a0aa754dfd9463790c2bf7de9e56c38
Source noteuspto-grants-2015_11