Nitrogen → HCID 69672155, compound

HRID 714224Notes

Reaction equation

HRID 714224 reaction equation
N#N.Br[CH2:4][CH2:5][CH2:6][CH2:7][OH:8].[F:9][C@H:10]1[CH2:14][CH2:13][NH:12][CH2:11]1.C([O-])([O-])=O.[K+].[K+]>CC#N>[F:9][C@H:10]1[CH2:14][CH2:13][N:12]([CH2:4][CH2:5][CH2:6][CH2:7][OH:8])[CH2:11]1

Participants

6

Reactant 4

HCID 947NitrogenHCID 11430Potassium CarbonateHCID 1183884-BromobutanolHCID 7016277(S)-3-fluoropyrrolidine

Product 1

HCID 69672155HCID 69672155, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
100 °C

Procedure

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a suspension of 4-bromo-1-butanol (187 mg, 1.20 mmol), (S)-3-fluoropyrrolidine (186 mg, 1.44 mmol) and K2CO3 (392 mg, 1.56 mmol) in CH3CN (8 mL) was heated to 100° C. under microwave irradiations for 25 min. The mixture was then filtered and the solvent removed under reduced pressure to give the title compound as a colorless oil.

Workup

  1. filtrationThe mixture was then filtered
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-8a0aa754dfd9463790c2bf7de9e56c38
Source dataset
uspto-grants-2015_11
Patent number
US09187435B2

Reaction notes

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