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Benzoyl chloride → N-benzyl-2-(3-phenylpropanamido)-isonicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | Benzenepropanoyl chloride | HCID 64801 | — |
| 反応物 | 2-amino-N-benzylisonicotinamide | HCID 18752897 | — |
| 生成物 | N-benzyl-2-(3-phenylpropanamido)-isonicotinamide | HCID 67153848 | 42% |
反応手順
Following the procedure as describe in preparation of Example 5, making variations as required to replace benzoyl chloride with hydrocinnamoyl chloride, to react with 2-amino-N-benzylisonicotinamide, N-benzyl-2-(3-phenylpropanamido)-isonicotinamide was obtained in 42% yield: mp 177-179° C.; 1H NMR (300 MHz, CDCl3) δ 10.63 (s, 1H), 9.26 (s, 1H), 8.46-8.36 (m, 2H), 7.54-7.14 (m, 11H), 4.43 (s, 2H), 2.86-2.68 (m, 4H); MS (ES+) m/z 360.6 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09187426B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-208b01bac54d41f5847bf631a0693001 |
| 出典メモ | uspto-grants-2015_11 |