Propylenediamine → HCID 178521775, compound

HRID 714340Notes

Reaction equation

HRID 714340 reaction equation
NCC(N)C.[F:6][C:7]1[CH:8]=[C:9]([CH2:14][CH:15]([NH2:18])[CH2:16][NH2:17])[CH:10]=[C:11]([F:13])[CH:12]=1.[C:19]([NH:27][C:28]1[CH:29]=[C:30]([CH:34]=[CH:35][N:36]=1)[C:31](O)=O)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[F:6][C:7]1[CH:8]=[C:9]([CH:10]=[C:11]([F:13])[CH:12]=1)[CH2:14][CH:15]1[CH2:16][NH:17][C:31]([C:30]2[CH:34]=[CH:35][N:36]=[C:28]([NH:27][C:19](=[O:26])[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:29]=2)=[N:18]1

Participants

4

Reactant 3

HCID 6567PropylenediamineHCID 582477873-(3,5-Difluorophenyl)propane-1,2-diamineHCID 643938512-Benzamidoisonicotinic acid

Product 1

HCID 178521775HCID 178521775, compoundYield 24%

Procedure

Following the procedure as described in Example 9, making variations as required to replace 1,2-diaminopropane with 3-(3,5-difluorophenyl)propane-1,2-diamine to react with 2-benzamidoisonicotinic acid, N-(4-(4-(3,5-difluorobenzyl)-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide was obtained in 24% yield: MS (ES+) m/z 393.2 (M+1).

Sources & evidence

ORD record
ord-bce9c2773e8a43fc91ec8d35da525eb8
Source dataset
uspto-grants-2015_11
Patent number
US09187426B2

Reaction notes

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