Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trichloromethanethiol | HCID 6390 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Cyclohexylcarboxamidine | HCID 193051 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1423042-49-2 | HCID 65267255 | — |
Reaction Steps
Cyclohexanecarboximidamide (100 mg, 792 μmol) and DIPEA (512 mg, 3.96 mmol) in 10 mL DCM at 0-5° C. were treated with perchloromethyl mercaptan (147 mg, 792 μmol) in 5 mL DCM and stirred for 1 hr at 0-5° C. The mixture was concentrated in vacuo to give a brown solid which was used with out further purification in the subsequent step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09187440B2 |
|---|
| Source dataset | uspto-grants-2015_11 |
|---|
| ORD ID | ord-10a225bb09934310b118e4aec0f41614 |
|---|
| Source note | uspto-grants-2015_11 |
|---|
